Drug interactions
Glyburide + Testosterone
Severity: Minor
Glyburide and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may improve insulin sensitivity and lower glucose in some patients, which can add to the effect of glyburide. Hypoglycemia is possible, although the effect is usually small.
What this interaction means in plain words
Glyburide and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Additive glucose lowering through androgen-related changes in insulin sensitivity; evidence is limited.
What to do
Monitor blood glucose when testosterone is started, stopped or changed. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Glyburide with Testosterone?
MediHelp rates the interaction as minor. Glyburide and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may improve insulin sensitivity and lower glucose in some patients, which can add to the effect of glyburide. Hypoglycemia is possible, although the effect is usually small.
How serious is the interaction between Glyburide and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when testosterone is started, stopped or changed. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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