Drug interactions
Glyburide-metformin + Goserelin
Severity: Moderate
Glyburide-metformin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as goserelin can reduce insulin sensitivity and worsen glycemic control. Diabetic patients may need more intensive therapy.
What this interaction means in plain words
Glyburide-metformin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Goserelin belongs to Endocrine.
Why it happens
GnRH agonist-induced hypogonadism increases insulin resistance and adiposity, opposing antidiabetic effects.
What to do
Monitor blood glucose and HbA1c regularly during goserelin treatment and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Goserelin
Frequently asked questions
Can I take Glyburide-metformin with Goserelin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with GnRH agonists such as goserelin can reduce insulin sensitivity and worsen glycemic control. Diabetic patients may need more intensive therapy.
How serious is the interaction between Glyburide-metformin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly during goserelin treatment and intensify antidiabetic therapy if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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