Drug interactions
Glyburide-metformin + Lopinavir
Severity: Moderate
Glyburide-metformin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors, including lopinavir/ritonavir, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glyburide and metformin. Ritonavir may also affect glyburide levels, so glucose can shift in either direction.
What this interaction means in plain words
Glyburide-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake, opposing antidiabetic effect.
What to do
Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Lopinavir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors, including lopinavir/ritonavir, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glyburide and metformin. Ritonavir may also affect glyburide levels, so glucose can shift in either direction.
How serious is the interaction between Glyburide-metformin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen and adjust antidiabetic doses accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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