Drug interactions
Glyburide-metformin + Metolazone
Severity: Moderate
Glyburide-metformin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-like diuretic, can raise blood glucose and so weaken the effect of glyburide and metformin. Diuretic-induced volume depletion may also affect renal function and metformin clearance.
What this interaction means in plain words
Glyburide-metformin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and insulin resistance oppose the glucose-lowering effects, and volume depletion may reduce renal metformin elimination.
What to do
Monitor blood glucose, potassium and renal function after starting metolazone. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Metolazone
Frequently asked questions
Can I take Glyburide-metformin with Metolazone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, a thiazide-like diuretic, can raise blood glucose and so weaken the effect of glyburide and metformin. Diuretic-induced volume depletion may also affect renal function and metformin clearance.
How serious is the interaction between Glyburide-metformin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function after starting metolazone. Adjust antidiabetic therapy as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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