Drug interactions
Glyburide-metformin + Midodrine
Severity: Minor
Glyburide-metformin and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both midodrine's active metabolite and metformin are cleared by renal tubular secretion, so competition could modestly raise concentrations of either. Clinical impact is probably small.
What this interaction means in plain words
Glyburide-metformin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Midodrine belongs to Miscellaneous.
Why it happens
Theoretical competition for renal tubular secretion via cationic transporters.
What to do
No routine change is needed. Monitor renal function and blood pressure in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Glyburide-metformin with Midodrine?
MediHelp rates the interaction as minor. Glyburide-metformin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both midodrine's active metabolite and metformin are cleared by renal tubular secretion, so competition could modestly raise concentrations of either. Clinical impact is probably small.
How serious is the interaction between Glyburide-metformin and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor renal function and blood pressure in patients with renal impairment.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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