Drug interactions
Glyburide-metformin + Miglitol
Severity: Moderate
Glyburide-metformin and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol has been reported to lower glyburide exposure, and as an alpha-glucosidase inhibitor it also adds to glucose lowering. Hypoglycemia treatment requires oral glucose rather than sucrose.
What this interaction means in plain words
Glyburide-metformin and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Miglitol may reduce glyburide absorption, and alpha-glucosidase inhibition delays carbohydrate absorption, giving additive glucose lowering.
What to do
Monitor blood glucose when combining and adjust doses as needed. Treat hypoglycemia with glucose (dextrose), not sucrose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Glyburide-metformin with Miglitol?
MediHelp rates the interaction as moderate. Glyburide-metformin and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol has been reported to lower glyburide exposure, and as an alpha-glucosidase inhibitor it also adds to glucose lowering. Hypoglycemia treatment requires oral glucose rather than sucrose.
How serious is the interaction between Glyburide-metformin and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when combining and adjust doses as needed. Treat hypoglycemia with glucose (dextrose), not sucrose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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