Drug interactions
Glyburide-metformin + Ondansetron
Severity: Minor
Glyburide-metformin and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron may inhibit renal and hepatic organic cation transporters and MATE proteins, potentially raising metformin concentrations. This could increase the risk of metformin adverse effects, especially in renal impairment.
What this interaction means in plain words
Glyburide-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of OCT/MATE-mediated transport reduces metformin renal secretion.
What to do
No routine action is needed for short courses; monitor renal function and for gastrointestinal effects in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Glyburide-metformin with Ondansetron?
MediHelp rates the interaction as minor. Glyburide-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron may inhibit renal and hepatic organic cation transporters and MATE proteins, potentially raising metformin concentrations. This could increase the risk of metformin adverse effects, especially in renal impairment.
How serious is the interaction between Glyburide-metformin and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for short courses; monitor renal function and for gastrointestinal effects in patients with reduced renal function.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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