Drug interactions
Glyburide-metformin + Pretomanid
Severity: Moderate
Glyburide-metformin and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits BCRP, and glyburide is a BCRP substrate, so glyburide exposure may rise. This could increase hypoglycemia risk.
What this interaction means in plain words
Glyburide-metformin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of BCRP efflux increases glyburide exposure.
What to do
Monitor blood glucose during pretomanid therapy and lower the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Pretomanid
Frequently asked questions
Can I take Glyburide-metformin with Pretomanid?
MediHelp rates the interaction as moderate. Glyburide-metformin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid inhibits BCRP, and glyburide is a BCRP substrate, so glyburide exposure may rise. This could increase hypoglycemia risk.
How serious is the interaction between Glyburide-metformin and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during pretomanid therapy and lower the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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