Drug interactions
Glyburide-metformin + Ranolazine
Severity: Moderate
Glyburide-metformin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits the renal transporters OCT2 and MATE1, raising metformin exposure. This can increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Glyburide-metformin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of OCT2/MATE-mediated renal tubular secretion of metformin by ranolazine.
What to do
Limit the metformin dose when ranolazine 1000 mg twice daily is used, per labeling, and monitor glucose and renal function. Watch for symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Ranolazine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits the renal transporters OCT2 and MATE1, raising metformin exposure. This can increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Glyburide-metformin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the metformin dose when ranolazine 1000 mg twice daily is used, per labeling, and monitor glucose and renal function. Watch for symptoms of lactic acidosis.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
