Drug interactions
Glyburide-metformin + Risperidone
Severity: Moderate
Glyburide-metformin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and hyperglycemia, which may reduce the effectiveness of glyburide and metformin. Glycemic control can worsen after initiation or dose increases.
What this interaction means in plain words
Glyburide-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotic-related metabolic effects cause insulin resistance and hyperglycemia, opposing antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during risperidone treatment. Intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Glyburide-metformin with Risperidone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and hyperglycemia, which may reduce the effectiveness of glyburide and metformin. Glycemic control can worsen after initiation or dose increases.
How serious is the interaction between Glyburide-metformin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during risperidone treatment. Intensify antidiabetic therapy if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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