Drug interactions
Glyburide-metformin + Temsirolimus
Severity: Moderate
Glyburide-metformin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus frequently causes hyperglycemia and hyperlipidemia, which may reduce the effectiveness of glyburide-metformin. Antidiabetic requirements may rise during therapy.
What this interaction means in plain words
Glyburide-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
mTOR inhibition causes insulin resistance and impaired glucose metabolism.
What to do
Monitor fasting glucose before and during temsirolimus therapy and increase antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Temsirolimus?
MediHelp rates the interaction as moderate. Glyburide-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus frequently causes hyperglycemia and hyperlipidemia, which may reduce the effectiveness of glyburide-metformin. Antidiabetic requirements may rise during therapy.
How serious is the interaction between Glyburide-metformin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose before and during temsirolimus therapy and increase antidiabetic treatment as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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