Drug interactions
Glyburide-metformin + Trazodone
Severity: Minor
Glyburide-metformin and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has been associated with occasional changes in glucose levels, and in patients on glyburide-metformin this could modestly alter glycemic control. The effect is small and unpredictable and rarely of clinical consequence.
What this interaction means in plain words
Glyburide-metformin and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not well established.
What to do
No dose change is normally needed; check blood glucose when trazodone is started or stopped in patients with unstable diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Trazodone?
MediHelp rates the interaction as minor. Glyburide-metformin and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has been associated with occasional changes in glucose levels, and in patients on glyburide-metformin this could modestly alter glycemic control. The effect is small and unpredictable and rarely of clinical consequence.
How serious is the interaction between Glyburide-metformin and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; check blood glucose when trazodone is started or stopped in patients with unstable diabetes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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