Drug interactions
Glyburide-metformin + Trimipramine
Severity: Minor
Glyburide-metformin and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may occasionally lower blood glucose or blunt awareness of hypoglycemia symptoms, adding to the effect of glyburide and metformin. Clinically significant hypoglycemia is uncommon.
What this interaction means in plain words
Glyburide-metformin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; the mechanism is not firmly established.
What to do
Monitor blood glucose when trimipramine is started or stopped, and advise the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Trimipramine?
MediHelp rates the interaction as minor. Glyburide-metformin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may occasionally lower blood glucose or blunt awareness of hypoglycemia symptoms, adding to the effect of glyburide and metformin. Clinically significant hypoglycemia is uncommon.
How serious is the interaction between Glyburide-metformin and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trimipramine is started or stopped, and advise the patient about hypoglycemia symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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