Drug interactions
Glyburide-metformin + Vadadustat
Severity: Moderate
Glyburide-metformin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat can raise exposure to substrates of the BCRP efflux transporter, which includes glyburide. Higher glyburide levels may increase the risk of hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP, which reduces the efflux and clearance of its substrates.
What to do
Monitor blood glucose after vadadustat is started and reduce the glyburide dose if hypoglycemia develops. Counsel the patient on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Vadadustat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Glyburide-metformin with Vadadustat?
MediHelp rates the interaction as moderate. Glyburide-metformin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat can raise exposure to substrates of the BCRP efflux transporter, which includes glyburide. Higher glyburide levels may increase the risk of hypoglycemia.
How serious is the interaction between Glyburide-metformin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after vadadustat is started and reduce the glyburide dose if hypoglycemia develops. Counsel the patient on recognizing hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
