Drug interactions
Glyburide-metformin + Vortioxetine
Severity: Minor
Glyburide-metformin and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants affecting serotonin can modify glucose control, and hypoglycemia has occasionally been reported with antidiabetic drugs. The clinical effect is generally small.
What this interaction means in plain words
Glyburide-metformin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Vortioxetine belongs to Central Nervous System.
Why it happens
Possible additive glucose-lowering via serotonergic effects on insulin sensitivity; mechanism not firmly established.
What to do
Monitor blood glucose when vortioxetine is started or stopped and adjust the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Vortioxetine?
MediHelp rates the interaction as minor. Glyburide-metformin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants affecting serotonin can modify glucose control, and hypoglycemia has occasionally been reported with antidiabetic drugs. The clinical effect is generally small.
How serious is the interaction between Glyburide-metformin and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when vortioxetine is started or stopped and adjust the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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