Drug interactions
Glycerol phenylbutyrate + Methylprednisolone
Severity: Moderate
Glycerol phenylbutyrate and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
What this interaction means in plain words
Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
Why it happens
Glucocorticoid-induced protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen-scavenging effect.
What to do
Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Glycerol phenylbutyrate with Methylprednisolone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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