Drug interactions
Glycopyrrolate + Ipratropium
Severity: Moderate
Glycopyrrolate and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so combining them can increase anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and blurred vision. The risk is greater with systemic glycopyrrolate and in older patients.
What this interaction means in plain words
Glycopyrrolate and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation and tachycardia. Avoid the combination in narrow-angle glaucoma or bladder outlet obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Ipratropium?
MediHelp rates the interaction as moderate. Glycopyrrolate and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so combining them can increase anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and blurred vision. The risk is greater with systemic glycopyrrolate and in older patients.
How serious is the interaction between Glycopyrrolate and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and tachycardia. Avoid the combination in narrow-angle glaucoma or bladder outlet obstruction.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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