Drug interactions
Glycopyrrolate inhaled + Umeclidinium
Severity: Moderate
Glycopyrrolate inhaled and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic adverse effects. Dry mouth, urinary retention and worsening of narrow-angle glaucoma are the main concerns.
What this interaction means in plain words
Glycopyrrolate inhaled and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate muscarinic receptor antagonism with additive systemic exposure.
What to do
Avoid using two long-acting muscarinic antagonists together; select a single agent. Monitor for urinary and ocular symptoms if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Frequently asked questions
Can I take Glycopyrrolate inhaled with Umeclidinium?
MediHelp rates the interaction as moderate. Glycopyrrolate inhaled and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic adverse effects. Dry mouth, urinary retention and worsening of narrow-angle glaucoma are the main concerns.
How serious is the interaction between Glycopyrrolate inhaled and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting muscarinic antagonists together; select a single agent. Monitor for urinary and ocular symptoms if overlap occurs.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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