Drug interactions
Glycopyrronium + Ipratropium
Severity: Moderate
Glycopyrronium and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so combining systemic or inhaled glycopyrronium with ipratropium can increase anticholinergic effects including dry mouth, tachycardia, urinary retention and, with inhaled use, worsened glaucoma. Therapy duplication adds little benefit.
What this interaction means in plain words
Glycopyrronium and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid combining two antimuscarinic bronchodilators; if both are used, monitor for urinary retention, eye symptoms and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Glycopyrronium with Ipratropium?
MediHelp rates the interaction as moderate. Glycopyrronium and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so combining systemic or inhaled glycopyrronium with ipratropium can increase anticholinergic effects including dry mouth, tachycardia, urinary retention and, with inhaled use, worsened glaucoma. Therapy duplication adds little benefit.
How serious is the interaction between Glycopyrronium and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antimuscarinic bronchodilators; if both are used, monitor for urinary retention, eye symptoms and anticholinergic effects.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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