Drug interactions
Glycopyrronium + Succinylcholine
Severity: Minor
Glycopyrronium and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can cause bradycardia, especially with repeated doses, and glycopyrronium is often given beforehand to blunt this and reduce secretions. The combination is generally useful rather than harmful.
What this interaction means in plain words
Glycopyrronium and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrronium belongs to Respiratory; Succinylcholine belongs to Musculoskeletal.
Why it happens
Glycopyrronium blocks muscarinic receptors, counteracting the vagal stimulation and bradycardia produced by succinylcholine.
What to do
Monitor heart rate and rhythm during induction; no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Succinylcholine
Frequently asked questions
Can I take Glycopyrronium with Succinylcholine?
MediHelp rates the interaction as minor. Glycopyrronium and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine can cause bradycardia, especially with repeated doses, and glycopyrronium is often given beforehand to blunt this and reduce secretions. The combination is generally useful rather than harmful.
How serious is the interaction between Glycopyrronium and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm during induction; no dose change is needed.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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