Drug interactions
Glycopyrronium + Thioridazine
Severity: Moderate
Glycopyrronium and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has strong anticholinergic activity, so combining it with glycopyrronium markedly increases the risk of dry mouth, constipation, urinary retention, tachycardia and confusion. Anticholinergic-induced tachycardia may also be undesirable given thioridazine's QT-prolonging effects.
What this interaction means in plain words
Glycopyrronium and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and heart rate, and consider an alternative to one agent if effects are significant. Check ECG per thioridazine labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Thioridazine?
MediHelp rates the interaction as moderate. Glycopyrronium and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine has strong anticholinergic activity, so combining it with glycopyrronium markedly increases the risk of dry mouth, constipation, urinary retention, tachycardia and confusion. Anticholinergic-induced tachycardia may also be undesirable given thioridazine's QT-prolonging effects.
How serious is the interaction between Glycopyrronium and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and heart rate, and consider an alternative to one agent if effects are significant. Check ECG per thioridazine labeling.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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