Drug interactions
Glycopyrronium + Ziprasidone
Severity: Minor
Glycopyrronium and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has weak anticholinergic activity, so combining it with glycopyrronium may add to antimuscarinic effects such as dry mouth, constipation, urinary retention and tachycardia. The effect is usually mild, but it may matter in older patients or those with urinary obstruction or glaucoma.
What this interaction means in plain words
Glycopyrronium and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrronium belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive anticholinergic pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms such as urinary retention, constipation and tachycardia, and reduce the glycopyrronium dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Ziprasidone?
MediHelp rates the interaction as minor. Glycopyrronium and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone has weak anticholinergic activity, so combining it with glycopyrronium may add to antimuscarinic effects such as dry mouth, constipation, urinary retention and tachycardia. The effect is usually mild, but it may matter in older patients or those with urinary obstruction or glaucoma.
How serious is the interaction between Glycopyrronium and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as urinary retention, constipation and tachycardia, and reduce the glycopyrronium dose if they emerge.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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