Drug interactions
Glycopyrronium tosylate + Prochlorperazine
Severity: Minor
Glycopyrronium tosylate and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied to the skin and has modest systemic absorption, while prochlorperazine adds anticholinergic activity. Additive effects such as dry mouth, urinary hesitancy, blurred vision and constipation are possible.
What this interaction means in plain words
Glycopyrronium tosylate and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Ask patients about anticholinergic symptoms such as urinary hesitancy and blurred vision. Stop the topical product if significant effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Glycopyrronium tosylate with Prochlorperazine?
MediHelp rates the interaction as minor. Glycopyrronium tosylate and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical glycopyrronium tosylate is applied to the skin and has modest systemic absorption, while prochlorperazine adds anticholinergic activity. Additive effects such as dry mouth, urinary hesitancy, blurred vision and constipation are possible.
How serious is the interaction between Glycopyrronium tosylate and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about anticholinergic symptoms such as urinary hesitancy and blurred vision. Stop the topical product if significant effects occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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