Drug interactions
Glycopyrronium tosylate + Umeclidinium
Severity: Moderate
Glycopyrronium tosylate and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium tosylate is a topical cloth used for axillary hyperhidrosis and has limited but measurable systemic absorption. Combined with inhaled umeclidinium, additive anticholinergic effects are possible, such as dry mouth, urinary retention and mydriasis.
What this interaction means in plain words
Glycopyrronium tosylate and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for systemic anticholinergic effects, and take care to avoid transfer of the topical product to the eyes. Stop the topical product if urinary retention or visual symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Frequently asked questions
Can I take Glycopyrronium tosylate with Umeclidinium?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium tosylate is a topical cloth used for axillary hyperhidrosis and has limited but measurable systemic absorption. Combined with inhaled umeclidinium, additive anticholinergic effects are possible, such as dry mouth, urinary retention and mydriasis.
How serious is the interaction between Glycopyrronium tosylate and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic effects, and take care to avoid transfer of the topical product to the eyes. Stop the topical product if urinary retention or visual symptoms occur.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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