Drug interactions
Golimumab + Hydroxyurea
Severity: Moderate
Golimumab and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea suppresses bone marrow and golimumab blocks TNF-alpha, so the combination may increase infection and cytopenia risk.
What this interaction means in plain words
Golimumab and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Golimumab belongs to Musculoskeletal; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor complete blood counts and infection signs regularly. Reduce hydroxyurea for cytopenias and hold golimumab during serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Golimumab with Hydroxyurea?
MediHelp rates the interaction as moderate. Golimumab and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea suppresses bone marrow and golimumab blocks TNF-alpha, so the combination may increase infection and cytopenia risk.
How serious is the interaction between Golimumab and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and infection signs regularly. Reduce hydroxyurea for cytopenias and hold golimumab during serious infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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