Drug interactions
Golimumab + Tisagenlecleucel
Severity: Major
Golimumab and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Golimumab adds to the immunosuppression and infection risk of CAR T-cell therapy, which already causes cytopenias and hypogammaglobulinemia. TNF blockade could also theoretically affect CAR T-cell function or cytokine release.
What this interaction means in plain words
Golimumab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Tisagenlecleucel belongs to Oncology.
Why it happens
Additive immunosuppression; effect of TNF inhibition on CAR T-cell expansion is not well characterized.
What to do
Avoid golimumab around lymphodepletion and CAR T infusion unless clearly required, and monitor closely for infection if used. Coordinate timing with the cell therapy team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Golimumab with Tisagenlecleucel?
MediHelp rates the interaction as major. Golimumab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Golimumab adds to the immunosuppression and infection risk of CAR T-cell therapy, which already causes cytopenias and hypogammaglobulinemia. TNF blockade could also theoretically affect CAR T-cell function or cytokine release.
How serious is the interaction between Golimumab and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid golimumab around lymphodepletion and CAR T infusion unless clearly required, and monitor closely for infection if used. Coordinate timing with the cell therapy team.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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