Drug interactions
Goserelin + Lefamulin
Severity: Moderate
Goserelin and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval and goserelin may add to it through androgen suppression. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbances.
What this interaction means in plain words
Goserelin and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and correct potassium and magnesium. Consider a non-QT-prolonging antibiotic in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Goserelin with Lefamulin?
MediHelp rates the interaction as moderate. Goserelin and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin prolongs the QT interval and goserelin may add to it through androgen suppression. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Goserelin and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium. Consider a non-QT-prolonging antibiotic in patients with additional risk factors.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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