Drug interactions
Goserelin + Metformin-repaglinide
Severity: Minor
Goserelin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GnRH agonists can reduce insulin sensitivity and impair glucose tolerance, particularly with long-term use, which may reduce the effect of antidiabetic therapy.
What this interaction means in plain words
Goserelin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Goserelin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Sex hormone suppression leading to increased insulin resistance.
What to do
Monitor glucose or HbA1c periodically during goserelin treatment and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Goserelin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. GnRH agonists can reduce insulin sensitivity and impair glucose tolerance, particularly with long-term use, which may reduce the effect of antidiabetic therapy.
How serious is the interaction between Goserelin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose or HbA1c periodically during goserelin treatment and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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