Drug interactions
Goserelin + Methadone
Severity: Moderate
Goserelin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and methadone has the same effect, so combined use may increase the risk of torsades de pointes. The risk is greater with additional risk factors such as electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Goserelin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation from GnRH agonist-induced androgen suppression and methadone's effect on cardiac repolarization.
What to do
Obtain a baseline ECG and periodic QTc monitoring, and correct potassium and magnesium. Avoid adding other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Methadone?
MediHelp rates the interaction as moderate. Goserelin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and methadone has the same effect, so combined use may increase the risk of torsades de pointes. The risk is greater with additional risk factors such as electrolyte disturbance or cardiac disease.
How serious is the interaction between Goserelin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and periodic QTc monitoring, and correct potassium and magnesium. Avoid adding other QT-prolonging drugs where possible.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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