Drug interactions
Goserelin + Ofloxacin
Severity: Moderate
Goserelin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and ofloxacin has a smaller QT-prolonging effect of its own. Together they may raise the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Goserelin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through different pharmacodynamic pathways.
What to do
Correct hypokalemia and hypomagnesemia and obtain a baseline ECG in patients with other QT risk factors. Consider an antibiotic with less QT effect if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Ofloxacin?
MediHelp rates the interaction as moderate. Goserelin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and ofloxacin has a smaller QT-prolonging effect of its own. Together they may raise the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Goserelin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and obtain a baseline ECG in patients with other QT risk factors. Consider an antibiotic with less QT effect if risk is high.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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