Drug interactions
Goserelin + Pitolisant
Severity: Moderate
Goserelin and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval and goserelin may add to this effect through androgen deprivation. Arrhythmia risk is mainly of concern in patients with other cardiac risk factors.
What this interaction means in plain words
Goserelin and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Pitolisant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes and repeat after initiation. Avoid the pair in patients with congenital long QT, bradycardia or hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Goserelin with Pitolisant?
MediHelp rates the interaction as moderate. Goserelin and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval and goserelin may add to this effect through androgen deprivation. Arrhythmia risk is mainly of concern in patients with other cardiac risk factors.
How serious is the interaction between Goserelin and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat after initiation. Avoid the pair in patients with congenital long QT, bradycardia or hypokalemia.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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