Drug interactions
Goserelin + Sorafenib
Severity: Moderate
Goserelin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and androgen deprivation with goserelin may contribute as well. Together they may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Goserelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation from sorafenib and goserelin-induced androgen deprivation.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Sorafenib
Frequently asked questions
Can I take Goserelin with Sorafenib?
MediHelp rates the interaction as moderate. Goserelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and androgen deprivation with goserelin may contribute as well. Together they may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Goserelin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium deficits.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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