Drug interactions
Goserelin + Vandetanib
Severity: Major
Goserelin and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Goserelin-induced androgen suppression can add to QT prolongation, increasing arrhythmia risk.
What this interaction means in plain words
Goserelin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Goserelin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid concurrent use if an alternative exists; otherwise perform baseline and serial ECGs and correct electrolytes (K, Mg, Ca). Interrupt vandetanib if QTc rises substantially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Goserelin and Vandetanib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Goserelin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Goserelin with Vandetanib?
MediHelp rates the interaction as major. Goserelin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Goserelin-induced androgen suppression can add to QT prolongation, increasing arrhythmia risk.
How serious is the interaction between Goserelin and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative exists; otherwise perform baseline and serial ECGs and correct electrolytes (K, Mg, Ca). Interrupt vandetanib if QTc rises substantially.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
