Drug interactions
Granisetron + Histrelin
Severity: Moderate
Granisetron and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and granisetron may add a small effect. The combined risk is usually low but relevant in patients with cardiac disease.
What this interaction means in plain words
Granisetron and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; androgen deprivation therapy is associated with QT prolongation.
What to do
Review the patient's QT risk factors and electrolytes. Obtain an ECG if granisetron is used repeatedly or alongside other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Granisetron with Histrelin?
MediHelp rates the interaction as moderate. Granisetron and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and granisetron may add a small effect. The combined risk is usually low but relevant in patients with cardiac disease.
How serious is the interaction between Granisetron and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the patient's QT risk factors and electrolytes. Obtain an ECG if granisetron is used repeatedly or alongside other QT-prolonging drugs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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