Drug interactions
Granisetron + Mifepristone
Severity: Moderate
Granisetron and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can prolong the QT interval, particularly at the higher doses used for Cushing's syndrome. Granisetron adds a small QT effect, so the combination may raise arrhythmia risk. Low single-dose use in pregnancy termination carries less concern.
What this interaction means in plain words
Granisetron and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
With chronic mifepristone, monitor the ECG and electrolytes before and during granisetron use. Consider an alternative antiemetic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Granisetron with Mifepristone?
MediHelp rates the interaction as moderate. Granisetron and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can prolong the QT interval, particularly at the higher doses used for Cushing's syndrome. Granisetron adds a small QT effect, so the combination may raise arrhythmia risk. Low single-dose use in pregnancy termination carries less concern.
How serious is the interaction between Granisetron and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With chronic mifepristone, monitor the ECG and electrolytes before and during granisetron use. Consider an alternative antiemetic if the QTc is prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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