Drug interactions
Granisetron + Primaquine
Severity: Moderate
Granisetron and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine has been associated with QT prolongation, and granisetron may add to this effect. The combination may modestly raise arrhythmia risk, especially with other QT-prolonging drugs.
What this interaction means in plain words
Granisetron and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check the ECG and electrolytes in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Granisetron with Primaquine?
MediHelp rates the interaction as moderate. Granisetron and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine has been associated with QT prolongation, and granisetron may add to this effect. The combination may modestly raise arrhythmia risk, especially with other QT-prolonging drugs.
How serious is the interaction between Granisetron and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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