Drug interactions
Granisetron + Propafenone
Severity: Major
Granisetron and Propafenone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a class 1C antiarrhythmic that prolongs QRS and can prolong QT with proarrhythmic effects. Granisetron adds a modest QT effect, so the combined risk of ventricular arrhythmia may rise.
What this interaction means in plain words
Granisetron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction and repolarisation.
What to do
Check baseline ECG and electrolytes, and monitor the ECG during therapy. Consider an alternative antiemetic if structural heart disease or other QT risks are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Granisetron with Propafenone?
MediHelp rates the interaction as major. Granisetron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propafenone is a class 1C antiarrhythmic that prolongs QRS and can prolong QT with proarrhythmic effects. Granisetron adds a modest QT effect, so the combined risk of ventricular arrhythmia may rise.
How serious is the interaction between Granisetron and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor the ECG during therapy. Consider an alternative antiemetic if structural heart disease or other QT risks are present.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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