Drug interactions
Granisetron + Quetiapine
Severity: Moderate
Granisetron and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so used together they may increase the chance of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, overdose or other QT-prolonging drugs.
What this interaction means in plain words
Granisetron and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Correct potassium and magnesium and obtain an ECG if other risk factors exist. Use the lowest effective doses and review other QT-prolonging medicines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Granisetron with Quetiapine?
MediHelp rates the interaction as moderate. Granisetron and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so used together they may increase the chance of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, overdose or other QT-prolonging drugs.
How serious is the interaction between Granisetron and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain an ECG if other risk factors exist. Use the lowest effective doses and review other QT-prolonging medicines.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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