Drug interactions
Granisetron + Tetrabenazine
Severity: Moderate
Granisetron and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes dose-related QT prolongation, and granisetron may add to this. The risk is higher in patients with congenital long QT, bradycardia or electrolyte abnormalities.
What this interaction means in plain words
Granisetron and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Obtain an ECG and correct electrolytes before combining, and monitor during therapy. Use another antiemetic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Granisetron with Tetrabenazine?
MediHelp rates the interaction as moderate. Granisetron and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes dose-related QT prolongation, and granisetron may add to this. The risk is higher in patients with congenital long QT, bradycardia or electrolyte abnormalities.
How serious is the interaction between Granisetron and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes before combining, and monitor during therapy. Use another antiemetic if the QTc is prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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