Drug interactions
Granisetron + Tranylcypromine
Severity: Major
Granisetron and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine is a nonselective irreversible MAO inhibitor with substantial risk of serotonin syndrome with serotonergic drugs. Granisetron adds a small additional serotonergic risk, and the outcome could be severe.
What this interaction means in plain words
Granisetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive serotonergic effect on top of irreversible MAO inhibition.
What to do
Choose a non-serotonergic antiemetic where possible. If granisetron is essential, monitor closely for serotonin toxicity and stop it if signs appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Granisetron with Tranylcypromine?
MediHelp rates the interaction as major. Granisetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is a nonselective irreversible MAO inhibitor with substantial risk of serotonin syndrome with serotonergic drugs. Granisetron adds a small additional serotonergic risk, and the outcome could be severe.
How serious is the interaction between Granisetron and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-serotonergic antiemetic where possible. If granisetron is essential, monitor closely for serotonin toxicity and stop it if signs appear.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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