Drug interactions
Granisetron + Vardenafil
Severity: Moderate
Granisetron and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil can cause small increases in QT interval and granisetron has a similar effect, so the combination may add to QT risk. This matters mainly in patients with congenital long QT, heart disease or electrolyte abnormalities.
What this interaction means in plain words
Granisetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Avoid the combination in patients with congenital long QT syndrome or other QT-prolonging drugs. Otherwise obtain an ECG if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Granisetron with Vardenafil?
MediHelp rates the interaction as moderate. Granisetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil can cause small increases in QT interval and granisetron has a similar effect, so the combination may add to QT risk. This matters mainly in patients with congenital long QT, heart disease or electrolyte abnormalities.
How serious is the interaction between Granisetron and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with congenital long QT syndrome or other QT-prolonging drugs. Otherwise obtain an ECG if risk factors are present.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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