Drug interactions
Granisetron + Voclosporin
Severity: Moderate
Granisetron and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin at supratherapeutic doses prolongs the QT interval, and granisetron may add a small effect. The combination may modestly raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Granisetron and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Check potassium and magnesium and obtain an ECG in patients with cardiac disease or other QT-prolonging medicines. Correct electrolyte abnormalities before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Granisetron with Voclosporin?
MediHelp rates the interaction as moderate. Granisetron and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin at supratherapeutic doses prolongs the QT interval, and granisetron may add a small effect. The combination may modestly raise arrhythmia risk in susceptible patients.
How serious is the interaction between Granisetron and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain an ECG in patients with cardiac disease or other QT-prolonging medicines. Correct electrolyte abnormalities before use.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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