Drug interactions
Grapefruit + Medroxyprogesterone
Severity: Minor
Grapefruit and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice may increase oral medroxyprogesterone exposure by inhibiting intestinal CYP3A4. The clinical effect is probably small.
What this interaction means in plain words
Grapefruit and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Grapefruit components inhibit intestinal CYP3A4, reducing first-pass metabolism.
What to do
Avoid regular large amounts of grapefruit juice with oral medroxyprogesterone, and monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Grapefruit with Medroxyprogesterone?
MediHelp rates the interaction as minor. Grapefruit and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice may increase oral medroxyprogesterone exposure by inhibiting intestinal CYP3A4. The clinical effect is probably small.
How serious is the interaction between Grapefruit and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular large amounts of grapefruit juice with oral medroxyprogesterone, and monitor for progestogenic adverse effects.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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