Drug interactions
Griseofulvin + Levoketoconazole
Severity: Minor
Griseofulvin and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of CYP3A4 and may lower levoketoconazole exposure. The reduction is probably modest, but it could reduce cortisol-lowering effect in Cushing's syndrome.
What this interaction means in plain words
Griseofulvin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Levoketoconazole belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by griseofulvin may increase levoketoconazole metabolism.
What to do
Monitor urinary free cortisol and clinical response if both are used together, and adjust the levoketoconazole dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Griseofulvin and Levoketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Griseofulvin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Griseofulvin with Levoketoconazole?
MediHelp rates the interaction as minor. Griseofulvin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of CYP3A4 and may lower levoketoconazole exposure. The reduction is probably modest, but it could reduce cortisol-lowering effect in Cushing's syndrome.
How serious is the interaction between Griseofulvin and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary free cortisol and clinical response if both are used together, and adjust the levoketoconazole dose according to response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
