Drug interactions
Griseofulvin + Linagliptin
Severity: Moderate
Griseofulvin and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin, an enzyme inducer, is expected to lower linagliptin exposure and could weaken glycemic control. The legacy direction of effect is inconsistent with induction.
What this interaction means in plain words
Griseofulvin and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Linagliptin belongs to Endocrine.
Why it happens
Induction of CYP3A4 and P-glycoprotein is expected to increase linagliptin clearance.
What to do
Monitor blood glucose and HbA1c, and consider an alternative antidiabetic agent if glycemic control worsens during griseofulvin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Griseofulvin with Linagliptin?
MediHelp rates the interaction as moderate. Griseofulvin and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin, an enzyme inducer, is expected to lower linagliptin exposure and could weaken glycemic control. The legacy direction of effect is inconsistent with induction.
How serious is the interaction between Griseofulvin and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and consider an alternative antidiabetic agent if glycemic control worsens during griseofulvin therapy.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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