Drug interactions
Griseofulvin + Lopinavir
Severity: Moderate
Griseofulvin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is cleared by CYP3A4, so griseofulvin may lower its concentrations. Although it is boosted with ritonavir, reduced exposure could compromise viral suppression.
What this interaction means in plain words
Griseofulvin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Lopinavir belongs to Anti Virals.
Why it happens
Griseofulvin induces CYP3A4, increasing lopinavir clearance.
What to do
Monitor HIV viral load and consider lopinavir level monitoring. Limit the griseofulvin duration or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Griseofulvin with Lopinavir?
MediHelp rates the interaction as moderate. Griseofulvin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is cleared by CYP3A4, so griseofulvin may lower its concentrations. Although it is boosted with ritonavir, reduced exposure could compromise viral suppression.
How serious is the interaction between Griseofulvin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider lopinavir level monitoring. Limit the griseofulvin duration or choose an alternative.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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