Drug interactions
Griseofulvin + Ondansetron
Severity: Minor
Griseofulvin and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer and could reduce ondansetron exposure somewhat. Multiple clearance pathways limit the likelihood of a meaningful effect.
What this interaction means in plain words
Griseofulvin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Griseofulvin induces hepatic CYP3A4, increasing ondansetron metabolism.
What to do
No routine dose change; monitor antiemetic response during prolonged griseofulvin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Ondansetron?
MediHelp rates the interaction as minor. Griseofulvin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a CYP3A4 inducer and could reduce ondansetron exposure somewhat. Multiple clearance pathways limit the likelihood of a meaningful effect.
How serious is the interaction between Griseofulvin and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor antiemetic response during prolonged griseofulvin therapy.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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