Drug interactions
Griseofulvin + Padeliporfin
Severity: Major
Griseofulvin and Padeliporfin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Padeliporfin is a photosensitizer activated by light, and griseofulvin is itself photosensitizing. Together they raise the risk of skin phototoxicity and unintended tissue injury.
What this interaction means in plain words
Griseofulvin and Padeliporfin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Padeliporfin belongs to Oncology.
Why it happens
Additive photosensitization from two photosensitizing agents.
What to do
Stop griseofulvin at least 10 days before padeliporfin and do not restart for at least 3 days afterward, or substitute a non-photosensitizing drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Padeliporfin
- Acetylsalicylic acid + Padeliporfin Major
- Amiodarone + Padeliporfin Major
- Bosentan + Padeliporfin Moderate
- Glyburide + Padeliporfin Moderate
- Padeliporfin + Repaglinide Moderate
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Padeliporfin?
MediHelp rates the interaction as major. Griseofulvin and Padeliporfin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Padeliporfin is a photosensitizer activated by light, and griseofulvin is itself photosensitizing. Together they raise the risk of skin phototoxicity and unintended tissue injury.
How serious is the interaction between Griseofulvin and Padeliporfin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop griseofulvin at least 10 days before padeliporfin and do not restart for at least 3 days afterward, or substitute a non-photosensitizing drug.
What other medicines interact with Padeliporfin?
MediHelp also lists interactions of Padeliporfin with, for example, Acetylsalicylic acid, Amiodarone, Bosentan. The full list is on the Padeliporfin page.
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