Drug interactions
Amiodarone + Padeliporfin
Severity: Major
Amiodarone and Padeliporfin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a well-known photosensitizing drug and may add to the light-related toxicity of padeliporfin. This raises the risk of phototoxic skin reactions.
What this interaction means in plain words
Amiodarone and Padeliporfin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Padeliporfin belongs to Oncology.
Why it happens
Additive photosensitization; amiodarone also persists in tissues for a long time.
What to do
Where feasible, stop or replace amiodarone at least 10 days before and for at least 3 days after treatment, recognizing its long half-life; otherwise protect from light.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Padeliporfin
- Acetylsalicylic acid + Padeliporfin Major
- Griseofulvin + Padeliporfin Major
- Bosentan + Padeliporfin Moderate
- Glyburide + Padeliporfin Moderate
- Padeliporfin + Repaglinide Moderate
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Padeliporfin?
MediHelp rates the interaction as major. Amiodarone and Padeliporfin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone is a well-known photosensitizing drug and may add to the light-related toxicity of padeliporfin. This raises the risk of phototoxic skin reactions.
How serious is the interaction between Amiodarone and Padeliporfin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, stop or replace amiodarone at least 10 days before and for at least 3 days after treatment, recognizing its long half-life; otherwise protect from light.
What other medicines interact with Padeliporfin?
MediHelp also lists interactions of Padeliporfin with, for example, Acetylsalicylic acid, Griseofulvin, Bosentan. The full list is on the Padeliporfin page.
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