Drug interactions
Glyburide + Padeliporfin
Severity: Moderate
Glyburide and Padeliporfin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Padeliporfin may reduce hepatic uptake of glyburide through OATP inhibition, increasing exposure and the risk of hypoglycemia.
What this interaction means in plain words
Glyburide and Padeliporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Padeliporfin belongs to Oncology.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of glyburide.
What to do
Avoid glyburide on the infusion day and for at least 24 hours after. Monitor blood glucose if exposure cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Padeliporfin
- Acetylsalicylic acid + Padeliporfin Major
- Amiodarone + Padeliporfin Major
- Griseofulvin + Padeliporfin Major
- Bosentan + Padeliporfin Moderate
- Padeliporfin + Repaglinide Moderate
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Padeliporfin?
MediHelp rates the interaction as moderate. Glyburide and Padeliporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Padeliporfin may reduce hepatic uptake of glyburide through OATP inhibition, increasing exposure and the risk of hypoglycemia.
How serious is the interaction between Glyburide and Padeliporfin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid glyburide on the infusion day and for at least 24 hours after. Monitor blood glucose if exposure cannot be avoided.
What other medicines interact with Padeliporfin?
MediHelp also lists interactions of Padeliporfin with, for example, Acetylsalicylic acid, Amiodarone, Griseofulvin. The full list is on the Padeliporfin page.
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